AICAR (5‑Aminoimidazole‑4‑carboxamide ribonucleotide) 50 mg Lyophilized Vial
AICAR is a research‑grade metabolic modulator supplied as a lyophilized powder for investigator‑controlled reconstitution. As an AMPK activator, AICAR mimics aspects of cellular low‑energy signaling to promote glucose uptake, increase fat oxidation and support mitochondrial function.
Key Features
- Research‑grade metabolic activator (batch‑tested purity)
- Potent activator of AMPK (cellular energy sensor)
- Enhances glucose uptake and fatty‑acid oxidation in experimental models
- Supports mitochondrial biogenesis and cellular energy regulation
- Supplied lyophilized for custom reconstitution and dosing
- Typical format: 50 mg vial for research use
Product Specifications
- Product name: AICAR (5‑Aminoimidazole‑4‑carboxamide ribonucleotide) (Purity: >99+% HPLC)
- Category: Cellular & metabolic research compound
- Supplied in: Lyophilized powder in sterile vial + 3ml bac water
- Typical administration (research): Subcutaneous injection (model‑dependent)
- Storage (reconstituted): Refrigerate at 2–8 °C; use within 30 days; avoid freeze–thaw cycles
Mechanism of Action
AICAR is converted intracellularly to ZMP, which activates AMPK — a master regulator of cellular energy balance. AMPK activation shifts metabolism toward increased glucose uptake and fatty‑acid oxidation, promotes mitochondrial efficiency and can trigger downstream pathways associated with improved metabolic resilience.
Key Metabolic and Physical Benefits
- Enhanced Endurance: By stimulating the creation of new mitochondria (mitochondrial biogenesis) and boosting fatty acid oxidation, AICAR helps cells generate energy more efficiently. In preclinical animal research, this translated to significantly improved running endurance without prior training.
- Fat Loss & Weight Management: It shifts the body's primary energy source from glucose to fats, assisting in the breakdown of visceral fat and reducing overall body weight in subjects with metabolic syndrome.
- Improved Insulin Sensitivity: Research shows it promotes glucose uptake in skeletal muscle, normalizing blood sugar levels and improving glucose tolerance in obesity-induced insulin-resistant models.Reduced Inflammation: It has anti-inflammatory properties that can help protect organs from obesity-induced damage and combat chronic inflammation linked to metabolic diseases.
Suggested Research Notes & Dosing Context
- Research-only low-dose protocols: some experimental setups use 0.5–1.0 mg per day in humans for exploratory metabolic research, but data is sparse and not standardized.
Reconstitution Instructions for AICAR (50mg Vial)
- Reconstitution: Reconstitute with 3 mL of Bacteriostatic Water (BAC) to the 50 mg of AICAR.
- Concentration:
- After reconstitution: 50 mg / 3 mL = 16.67 mg/mL.
- Volume Calculations for Dosing:
- Volume for 1 mg: 3 mL / 50 mg = 0.06 mL (approximately 0.06 mL per 1 mg).
- Volume for 2 mg: 2 × 0.06 mL = 0.12 mL (approximately 0.12 mL per 2 mg).
- In Insulin Syringe Units (100 units = 1 mL):
- For 1 mg: 0.06 mL = 6 units.
- For 2 mg: 0.12 mL = 12 units.
Research Insights
- AICAR reliably activates AMPK in controlled settings, producing measurable effects on glucose transport, fatty‑acid oxidation and markers of mitochondrial activity.
- Because AMPK is a central metabolic regulator, AICAR is a useful tool to probe energy‑sensing pathways and downstream metabolic adaptations in cells and animal models.
Possible Observations and Adverse Events
- Model‑dependent effects; safety profile varies with dose and species
- High experimental doses in animal work exceed any established safe human dose
- Monitor metabolic parameters and overall health markers in study subjects
Storage, Stability and Handling After Reconstitution
- Reconstituted solutions: refrigerate at 2–8 °C and use within 30 days; protect from light; do not freeze
- Minimize freeze–thaw cycles and employ aseptic technique during handling
Safety and Handling
- For laboratory research use only.
- Follow institutional biosafety, chemical handling and waste disposal protocols.
- Use appropriate personal protective equipment (PPE) such as gloves, lab coat and eye protection.
- In case of accidental exposure follow institutional incident procedures.
Legal and Regulatory Notice
By purchasing this product you confirm that you are acquiring it for lawful research purposes. It is the purchaser’s responsibility to ensure compliance with local laws, institutional policies, ethical and customs requirements. Liability for misuse is disclaimed.
