Understanding the Connection Between Brain Bleeds and Amyloid Deposits in Older Adults

Understanding the Connection Between Brain Bleeds and Amyloid Deposits in Older Adults

Understanding the Connection Between Brain Bleeds and Amyloid Deposits in Older Adults


In recent research conducted by Weill Cornell Medicine, New York-Presbyterian, and Yale School of Medicine, a groundbreaking discovery has been made regarding brain bleeds in older adults. It has been found that these brain bleeds, known as subdural hemorrhages, are linked to the presence of amyloid deposits in blood vessels within the brain. This study sheds light on the association between cerebral vessel amyloid and subdural hemorrhages and opens up new possibilities for better understanding and care for these conditions.

What are Subdural Hemorrhages?

Subdural hemorrhages are bleeding events that occur on the outer surface of the brain, just below the protective membrane called the dura. These bleeds result in the accumulation of trapped blood known as subdural hematomas. They can exert dangerous pressure on the brain and often require surgical intervention. With nearly 125,000 cases reported annually in the United States, subdural hemorrhages are becoming a common reason for brain surgery among older adults.

Exploring the Link between Amyloid Deposits and Subdural Hemorrhages

The study observed two large population-based cohorts, comprising more than 600,000 participants from the United Kingdom and the United States. It was found that individuals with amyloid deposits in their cerebral blood vessels, a condition known as cerebral amyloid angiopathy (CAA), were at least five times more likely to experience subdural hemorrhages compared to those without CAA.

Implications for Diagnosis and Treatment

Currently, subdural hemorrhages are not typically considered as part of the spectrum of cerebral amyloid angiopathy. However, this groundbreaking research suggests a paradigm shift in clinical practice. If the link between amyloid deposits and subdural hemorrhages is established, healthcare professionals may start screening and evaluating subdural hemorrhage patients for underlying CAA. This change in approach could lead to better care and improved outcomes for affected individuals.

Further Investigation and Prospective Studies

While this study provides significant evidence of a connection between amyloid deposits and subdural hemorrhages, further investigation is required. The next step involves conducting multicenter prospective studies using PET scans to detect the presence of amyloid in patients with isolated subdural hemorrhages. This research will help solidify the relationship between CAA and subdural hemorrhages and provide insights into potential treatments.

Potential Treatment Options

Currently, there are no specific treatments available for cerebral amyloid angiopathy. However, recent advancements in anti-amyloid therapies, approved for use in Alzheimer's disease, hold promise for potential use in CAA patients. As screening subdural hemorrhage patients for CAA becomes more common, it may identify individuals who could benefit from these treatments once they become available.


The groundbreaking research linking amyloid deposits in blood vessels to subdural hemorrhages in older adults brings us a step closer to understanding these conditions and revolutionizing their diagnosis and treatment. By uncovering the connection between cerebral vessel amyloid and subdural hemorrhages, healthcare professionals can implement proactive measures to provide better care and improve outcomes for affected individuals. Further research and clinical studies will help us unlock the full potential of this newfound knowledge and explore effective treatment options for cerebral amyloid angiopathy.

1. Study Links Subdural Hemorrhage to Cerebral Vessel Amyloid Deposits
2. Cerebral Amyloid Angiopathy
3. Cerebral amyloid angiopathy
4. β-Amyloid, Blood Vessels, and Brain Function
5. Vascular Amyloidosis
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